The Cardiovascular Health and Air Pollution Study (CHAPS), is a multidisciplinary
project which designed to investigate the effects of micro- environmental exposures
to PM on cardiovascular outcomes in elderly retirees affected by coronary artery
disease (CHD). The elderly population with CHD is likely to be among the most vulnerable
to the adverse effects of particulate air pollutants. In this regard, four sampling
sites located in retirement communities in Southern California were studied. In
all sites two stations: one indoors and one outdoors were set up. Sampling and analysis
were performed at two phases, one in colder period of year and the other one in
warmer period. Warmer phase was from July-Oct 2005 and July-Oct 2006 and colder
phase was Oct 2005-Feb 2006 and Oct 2006-Feb 2007, lasting 6 weeks each. Besides
online or continues pollutants measurements, 24h sampling from Monday to Friday
were performed at each site. In addition personal 24h samples were collected for
67 nonsmoker subjects with coronary heart diseases simultaneously. Online measurements
included these parameter: PM, EC, OC, PN, NO, NO2, CO, O3 . The 24h samples were
analyzed for 92 organic compounds, 52 Elements and Toxicity Analysis. Also biomarkers
of inflammation and thrombosis were determined for subjects. The main purpose of
the study was to investigate the effects of micro- environmental exposures to PM
on cardiovascular outcomes in elderly retirees affected by coronary artery disease.
Indoor PM of outdoor origin (mostly from combustion sources) was more significantly
associated with systemic inflammation, platelet activation, and decreases in erythrocyte
antioxidant activity than uncharacterized indoor PM that included particles of indoor
origin. Moreover, this project aimed to evaluate the composition and characteristics
of particulate matters in both indoor and outdoor environments, to identify the
most important sources of these pollutants, and to quantify their contribution to
the total PM mass concentrations in both indoor and outdoor environments. This project
was funded by the National Institute of Environmental Health Sciences (NIEHS), National
Institutes of Health, the National Center for Research Resources, the U.S. Environmental
Protection Agency, and the California Air Resources Board.
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